| Champion |
St. Louis Swarm 05
(13-3-0 in 2021)
|
18A
|
Arnold, MO
|
| Runner-Up |
Louisville Lady Sluggers 18u
(20-9-1 in 2021)
|
18B
|
Moscow Mills, MO
|
| |
ACO CRUSH
(1-7-0 in 2021)
|
18B
|
Payson, IL
|
| |
Cyclones
(16-27-0 in 2021)
|
18B
|
Imperial, MO
|
| |
Midwest Adrenaline 18u
(9-9-0 in 2021)
|
18B
|
Mount Sterling, IL
|
| |
Missouri Fury 04
(2-2-0 in 2021)
|
18B
|
New Melle, MO
|
| |
Tomahawks
(6-4-0 in 2021)
National Qualified
State Qualified
|
16A
|
O'Fallon, IL
|